منابع مشابه
Oncogenes in Human Cancer: A Review ras
Mutations in codon 12, 13, or 61 of one of the three ras genes, 11-ra.v, k-ra.v, and N-ra.v,convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, althou...
متن کاملras Oncogenes in Human Cancer: A Review1
Mutations in codon 12, 13, or 61 of one of the three ras genes, 11-ra.v, k-ra.v, and N-ra.v,convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, althou...
متن کاملbeta-Catenin and ras oncogenes detect most human colorectal cancer.
UNLABELLED PURPOSE AND STUDY DESIGN: Recent studies have shown that beta-catenin translocated into the cell nucleus functions like an oncogene. Accumulating evidence suggests that activation of the beta-catenin oncogenic signaling cascade along with its twin, the K-ras cascade, may exert syngeneic or synergistic effects on tumor development and progression. In the study reported here, we analyz...
متن کاملTransforming ras oncogenes and multistage carcinogenesis.
Transforming ras oncogenes and multistage carcinogenesis Few topics have caught the imagination of both clinicians and scientists in the field of cancer research as readily as the recent studies on oncogenes and their role in tumour development. The first identification of transforming genes in human tumours (Der et al., 1982; Parada et al., 1982; Santos et al., 1982) was greeted in certain cir...
متن کاملActivated ras Oncogenes in Human Thyroid Cancers1
Human thyroid epithelial (follicular) cells give rise to two malignant tumors—"follicular" carcinomas, which metastasize almost exclusively via the bloodstream, and "papillary" carcinomas, which metastasize predominantly via lymphatics (Williams, E. D. In: W. Duncan (ed.), Recent Results in Cancer Research: Thyroid Cancer, pp. 47-55. Berlin: Springer-Verlag, 1980). We have investigated whethe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 1984
ISSN: 0028-0836,1476-4687
DOI: 10.1038/310448a0